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Compared with our ART costing assumptions, the costs of ART may even increase if treatment initiation criteria are widened (to earlier stages of infection/disease) in coming years, due to longer therapy and an increasing need for more expensive second- and third-line regimens.
Unit costs, data sources and main costing assumptions.
Second, several sensitivity analyses were performed to see whether costing assumptions changed the results.
The costing assumptions were developed by professionals with specific experience in managing patients with LTnC.
Additional details and costing assumptions can be found in the Supplementary Appendix.
See the Additional file 1 for further details on costing assumptions and ingredient cost estimates.
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Robustness to cost assumptions was tested in univariate sensitivity analyses.
Therefore, in the second part of this analysis (S7b), we used an alternative unit cost of €50 per point, corresponding to the three daily ICU period-specific unit cost assumptions used in the base case analysis (see ' Unit cost assumptions ' section above).
However, LE assumptions, cost assumptions, and projected clinical and economic results were similar to those previously reported [ 41, 42], and we tested the impact of biologic and operational assumptions in extensive sensitivity analyses [ 10, 14].
Total intensive care unit (ICU) costs with dexmedetomidine and current standard care sedatives in the 18 centers whose routine daily ICU cost information the unit cost assumptions in this work were based on (S7).
The unit cost assumptions were built on the mean daily ICU costs obtained from 18 trial centers, representing six out of nine study countries, and 34% of all patients included in this economic analysis.
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