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Using these distributions, the probability of each formula being cost-effective at different cost-effectiveness thresholds was estimated.
The results from both studies show that treating all patients irrespective of fibrosis level is cost-effective at UK cost-effectiveness thresholds.
In addition, a cost-effectiveness acceptability curve is constructed, which shows the probability that the SLIMMER intervention is cost-effective for a range of cost-effectiveness thresholds.
Given that the ICER for bCPAP versus nasal oxygen is US$4.20 per LY gained, the bCPAP would be considered highly cost-effective by the international standards (assuming that the cost-effectiveness thresholds can be extended from DALYs to LYs).
The PSA showed that at acceptable cost-effectiveness thresholds LMP had a high probability of being cost-effective compared with pregabalin both in Austria and Portugal.
PSA showed that at acceptable cost-effectiveness thresholds of €20,000 30,000 per QALY, the lidocaine plaster had a high probability of being cost-effective compared with both gabapentin and pregabalin.
In terms of cost-effectiveness, the incremental cost per LY gained and QALY gained was compared with cost-effectiveness thresholds.
Results were expressed in cost per quality-adjusted life-year gained and cost per life-year gained and compared with cost-effectiveness thresholds.
Orphan drugs frequently present ICER values far above established cost-effectiveness thresholds, but this is not the case with azacitidine, which has a low ICER value compared with other orphan drugs [23 28].
As there are no RP specific cost-effectiveness analyses available it is highly likely that the ARMD cost-effectiveness thresholds will be applied which will result in a relatively high WTP threshold located around €80,000 per QALY gained.
Similar(1)
Table 2 shows the probability of screening being cost effective at different cost effectiveness thresholds under the six different scenarios for the effect of screening on breast cancer incidence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com