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This relationship could be considered from another point of view, ie, treatment ameliorates the disease but at the cost of side effects which worsen quality of life.
The cost neutral point was at 3.5 years, when the upfront cost of SC (plus any subsequent cumulative cost of side effects and ADT) equates the cumulative cost in the ADT arm.
This consisted of varying the number of QALYs gained for nab-paclitaxel and docetaxel, the drug acquisition cost of paclitaxel and docetaxel, as well as the cost of side effects and the overall cost per course for these agents by ±10%.
Similar(57)
Using univariate analyses we assessed the impact of variations in rituximab costs, hospitalization costs, salvage treatment costs, costs of side effects, average monthly index of consumption prices and discount rates.
The choice between two equally effective treatments, such as breast-conserving therapy and mastectomy, may have other implications for well being than the choice between a treatment that has the potential to increase the chance of being cured at the costs of side effects, or no treatment.
Overall, this study provided no evidence that the cost implications of side effects and serious adverse events (requiring prescribed medication or hospital admission) differ between regimens.
The choice is reduced simply to one of cost versus of side effects (eg, a choice of B over A would imply that the respondent is willing to pay an extra $75 per month to avoid the side effect of nausea).
Even a doubling the cost of side-effects management had only a marginal effect on the final cost per QALY estimates.
They assessed them for their cost-effectiveness, discomfort/presence of side effects, and for convenience of access and use.
And parents have been discouraged by their high cost and fears of side effects.
Dr. Arthur Margolin, a research scientist in the department of psychiatry at Yale's medical school and lead author of the report, said that among the benefits of acupuncture were its low cost and lack of side effects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com