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Costs are mainly driven by injection frequencies and cost of blindness.
Therefore, most of the NMB stems from cost reductions (including the cost of blindness) and not QALY gains.
The cost of blindness was associated with individuals whose BCVA was less than 35 letters (Table S2).
The lifetime cost of blindness was lower for patients receiving ranibizumab (−£3,920) or vPDT (−2,138) than for patients under observation.
As such, the base case model adjusts for the cost of blindness on the basis of treated eyes reaching the BCVA ≤35-letter threshold.
The cost of blindness to the Australian government and community was estimated at between AUS$ 9,749 and AUS$26,7200 per patient per year [ 2].
Similar(47)
In this paper, we refer to cost per QALY, cost per case of blindness averted and cost per blind-year averted as cost-effectiveness ratios, an approach that is standard in the United States.
But, at the same time, you can't leave; you want to see how the discomfort will mount, what the costs of blindness will be.
25 Costs of blindness included those incurred by the UK National Health Service for items such as low-vision aids, low-vision rehabilitation, residential or home care, depression and hip fracture/replacement as listed in the costing study by Meads and Hyde.
The results are not comparable with the current study because of significant differences in methodology, including a 1-year time horizon, perspective and the absence of costs of blindness in the US study.
Under the base-case scenario, the cost per case of blindness prevented varied from $13,200 to $217,700, and the cost per QALY gained varied from $5,600 to $91,900, depending on the ranibizumab cost.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com