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Compared to the apocalyptic best-night-of-your-life energy that Martin and Cost manifested at Cavo Paradiso, the day party was low-key and relaxed but no less enjoyable.
To parameterize the 'deleterious mutant' scenario, we assumed that the in vitro fitness cost manifested itself through a reduction in the within-host viral production rate.
These two strains seemed to incur a heavy cost manifested by growth defects even at non-restrictive temperatures and had defects in translation as seen from kinetics of induction of a reporter gene (β-gal in their assay).
This fitness cost, manifested as a reduced competitive ability in the absence of the antibiotic (Andersson 2006), often arises from the effects of resistance mutations on the function, stability, and folding of the protein targeted by the antibiotics (DePristo et al. 2005; MacLean et al. 2010a).
Similar(56)
"When a workplace is unhealthy or even toxic," she says, "increased costs manifest themselves in a variety of different areas healthcare costs, leave of absence data, productivity and even overtime requests".
Consequently, evidence regarding the individual (versus economic or societal) costs of mood disorders--and especially how these costs manifest among populations with bipolar disorder versus depression and no mood disorder--is extremely limited.
From an experimental standpoint, faced with the physical limitation set by a maximum achievable Rabi rate, this cost manifests as a longer total sequence duration (tau= hat {sigma }_{l}^{n}tau_{l}).
In endemic settings, this fitness cost manifests as a reduced prevalence of mutant pfcrt or pfmdr1 following the release of selective drug pressure [ 32– 32].
All of these will cost energy, manifested as greater blood supply to these brain regions.
Since the rise in drug costs has manifested a plateau from 2009 onwards, no relevant further increase in total costs for patients with RA treated in German rheumatology is expected.
Such survival costs were manifested in later breeding episodes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com