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A better understanding of the natural history and epidemiology of HPV feeds into models of vaccine impact and cost effectiveness to inform decision-making on HPV immunisation and future changes to cervical screening.
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The strengths of the IDEAL Project lie in its pragmatic nature [ 43, 44], which is expected to enhance external validity and inform understanding of effectiveness, implementation, and cost-effectiveness to inform future development and adaptation.
Our study provides novel data that can be used in decision analyses and cost effectiveness studies to inform clinical practice guidelines, which to date have relied on extrapolations of general population data.
Many HTA agencies use cost-effectiveness analysis to inform such decisions, where cost-effectiveness is expressed using incremental cost-effectiveness ratios (ICERs).
The present model utilised several resource and costing data sources (Table 1) as well as a number of clinical and cost-effectiveness studies to inform patient characteristics and data on adverse events, discontinuation rates, and relapses [ 38- 42].
Probabilistic sensitivity analysis (PSA) is commonly applied in cost-effectiveness analysis to inform healthcare stakeholders of parameter uncertainty.
Nevertheless, the potential for cost-effectiveness analysis to inform policy decisions is also great.
There are at present insufficient well conducted cost-effectiveness studies to inform decision-makers on the value for money of alternative mask/respirator options.
With the growing importance of cost-effectiveness estimation to inform Government and health insurers' policy decisions, it would be useful to be able to predict, or map, the EQ-5D index from other commonly collected demographics and clinical outcome variables.
These findings justify a definitive trial of this approach to improving medication adherence over a longer period of time, with clinical and cost-effectiveness outcomes to inform clinical practice.
Kim et al. have applied methods of operations research and cost-effectiveness analysis to inform the optimal selection of health interventions to package together with other single contact interventions such as cervical screening [ 30].
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