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In terms of PHN-cases avoided the most cost-effective age at vaccination is 65 years.
The most cost-effective age of vaccination changes from 50 to 60, when moving from best to worst booster scenario.
We did not set an upper age limit for participants as fruit and vegetable intake may be beneficial even in old age [ 34].We assessed the cost effectiveness of intervention in selected age groups of population which shows that intervention is more cost effective in older age groups.
Further follow-up needs to be undertaken to determine whether vaccination is efficacious and cost effective in adults age 50 59.
Similar to our results, a 2006 model by Maciosek and colleagues [ 29] concluded from their model that immunizing adults under age 65 was reasonably cost effective and immunizing adults age 65 and above was highly cost effective.
Similarly, the cost effectiveness acceptability curves in figure 2 and the values in table 4 show that hybrid prostheses were most likely to be cost effective for patients aged 70 that is, hybrid prostheses were associated with the highest net monetary benefit in most of the 1000 simulations in the probabilistic model.
25 Dabigatran 110 mg twice daily is not a cost effective option, and the age adjusted dosing regimen was dominated in all scenarios by the 150 mg dose.
Table 3 shows that a catch-up campaign in girls up to age 18 may be cost effective, but extending the campaign to age 25 is highly unlikely to be cost effective.
For example, the probability that dabigatran is cost effective for patients under the age of 80 years at the commonly cited WTP threshold of £20 000/QALY gained was 98% against warfarin, and 100% against aspirin and no treatment.
For most scenarios we found that it would be most cost effective to vaccinate young people aged 5-19 years (high transmitters).
ICERs for the subgroup pairs show that the intervention treatment was most cost effective for females and participants aged >65 years and to a lesser extent also for higher educated participants.
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