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To adjust for the lower weight of Spanish infants compared to infants from participating countries of the trial (e.g. US, UK, and Germany), an expert opinion-based drug cost calculation approach was employed.
A sophisticated drug cost calculation approach was presented in a previous economic evaluation for the UK, where palivizumab costs were estimated by the required dose, i.e., the number of 100-mg or 50-mg vials needed to administer palivizumab each month [17].
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Zeidler et al. [11] examined the effects of different approaches for cost calculation in claims data studies (control group approach vs. expert approach).
All the articles used a bottom-up approach (cost calculation progressing from most detailed to most general) for their cost analyses, although only 19.23% of the articles (n = 5) make explicit reference to this information.
Algorithm 1 acts as the basis for this strategy cost calculation since it presents the proposed approach.
The SSTC approach is based on maximum-likelihood based target cost calculation and it generated overly smooth trajectories in many cases which reduced its performance.
However, in the absence of a reliable cost calculation, this was considered to be an appropriate alternative for an approach in which factor concentrates represent more than 90%% of overall expenses (in severe patients and patients with inhibitors).
Fig. 3 LDR-HDR cost calculation comparison.
Feed cost, labor, housing costs and governmental supports were not taken into account for cost calculation.
Additional file 3 Molecular weight and cost calculation.
Cost calculation will be based on real prices or on unit prices from the Swiss Guideline for Cost Calculation.
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