Both oil-in-water and water-in-oil emulsions have been extensively used to deliver drugs and cosmetic agents to the skin, depending on the property of active agents and the indications of the medicines.
PDI has been used as an ingredient in cosmetic agents for treating hair (European Patent WO2003099243 A1).
Cell cultures are used to diagnose diseases of various etiologies, as test objects when testing new pharmacological, therapeutic, and cosmetic agents, as well as food additives [18].
Lactic acid bacteria fragments have shown antioxidant effects and whitening effects, and they increase the activity of cosmetic agents (Choi et al. 2013).
In Germany, 0.5 kg DEP can be used for denaturing 100 L ethanol for the production of cosmetic agents or agents used to improve the odour [38].
Although these cosmetic agents work well in vitro, only a few of them, such as hydroquinone and its derivatives, are able to induce decent hypopigmenting effects in clinical trials (Solano et al 2006).
The diversity of its economic importance varies from production of solvents - Clostridium beijerinckii, C. acetobutylicum, C. saccharoperbutylacetonicum and C. sachharobutylicum [ 5], biofuels such as ethanol and hydrogen - Clostridium thermocellum and C. acetobutylicum [ 6- 9], indigo dye and flax retting to enzymes as therapeutic and cosmetic agents [ 10].
The rapid developments in nanotechnology have allowed the incorporation of therapeutic agents, actives for cosmetic, sensing agents into nanoparticles, for detection, prevention, and treatment of skin diseases.
Kojic acid, a well-known tyrosinase inhibitor currently used as a cosmetic skin-whitening agent, was used as a positive control.
