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Consequently, clarifying the principles of thalamic computation is necessary to understand cortical operations.
The present evidence suggests a model for synthesizing neurodegenerative disease effects on these cortical operations that is consistent both with data from normal neurophysiological and functional neuroimaging work and the effects of focal brain lesions (Craig, 2002, 2009; Borsook, 2012).
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By having such direct input into a cortical operation, one can study its behavioral consequences and thereby ask questions about the requirement of ongoing activity for a cognitive operation.
The notification principle may be considered in addition to other ideas on cortical operation like the "just-enough and just-in-time" principle (Douglas and Martin 2007a) as it is concerned neither with the forward propagation of information nor the actual calculation, but with the preparation for the next operation.
Furthermore, the complex pattern of inhibitory interneurons in cortex is poorly understood and could certainly support similar intra-cortical operations.
Thus, the various cellular characteristics suggest that different interneuron types contribute differentially to cortical network operations.
This circuit represents the minimum architecture necessary for capturing the most essential cortical input-output operations of neocortex.
The output of the network is taken from the Ge neurons as we assume that the Ge neurons provide the input to higher-level cortical structures performing operations like phoneme categorization and providing access to lexicon.
Two months postoperation, cortical margin around operation site was distinct in panoramic view (Fig. 3a d).
The results of our study support with new evidence an important idea in cortical neurophysiology: higher cognitive operations develop from the modality-specific sensory cortices (in the present study, SI cortex) that are involved in sensation and perception of various stimuli.
Studies of grid cells may thus provide access to some of the basic computational operations of cortical circuits.
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