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First, training likely leads to increased recruitment of neuronal populations, as has been shown with expansion of the cortical hand area following skill training (Nudo et al., 1996).
For example, the forearm is located next to the hand in the somatotopic map [ 17, 18] and by anaesthetizing the forearm, the cortical hand area can expand over the forearm area [ 24].
The forearm is located next to the hand in the somatotopic map [ 13, 14] and by anaesthetizing the forearm, the cortical hand area can expand over the forearm area [ 46].
Similar(57)
In the MI group, similar to the ND group, cortical excitability of the motor cortex contralateral to the immobilized arm and the cortical representation of hand area significantly decreased after nonuse.
The animals of the present study are included in a protocol of cortical lesion of the hand area of M1 (see e.g. Hamadjida et al. 2012; Kaeser et al. 2010, 2011; Wyss et al. 2013).
This supports the idea that motor cortical areas other than the hand area may respond differently to tDCS or require greater stimulation.
Participants first performed a simple lip purse during fMRI (before and after the therapy), measured against rest, to establish the extent of cortical reorganization from face to hand area in motor and somatosensory representational maps (Lotze et al., 2001).
There is no clear understanding as to why deafferentation and subsequent expansion of the cortical representation of the face into the hand area causes pain, rather than just an abnormal perception.
Prior to training, activation elicited during lip purse showed evidence of cortical reorganization of motor (M1) and somatosensory (S1) cortices, expanding from lip area to hand area, which correlated with pain scores.
After a cortical response was elicited by magnetic stimulation of the hand area, high-density EEG recordings showed activation of the adjacent ipsilateral motor area, which then spread to homologous regions of the opposite hemisphere [31], [32].
Dependent variable: cortical hand bone loss (yes/no).
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