Applying ARG-walker to the haplotype data of JPT+CHB population of HapMap Phase 3, we detected strong cis-regulatory signals that can corroborate the function of the 13-mer PRDM9 binding motif CCNCCNTNNCCNC, which is known to be critical for the regulation of meiotic recombination hotspots of human.
This corroborates the reported function of dysferlin as a vesicular protein.
Scoring largely improves when protein function as encoded by Gene Ontology terms is considered, corroborating the role of protein function as a key feature for a correct annotation of its variations.
Different substrate and peptide bond specificities between the two isoforms have been previously described [13], and their differential activity towards E-cadherin corroborates the distinct functions of both subunits.
The congruence of phylogenetic grouping and gene cluster structure (Fig. 3) strongly corroborates the attribution of function suggested by the observed clade.
An additional set of experiments was carried out to corroborate the likelihood function (55).
Collectively, these studies have corroborated the protective function of Smad7 in attenuating TGF-β-mediated fibrosis in multiple organs.
These data corroborated the Nβ function as a novel signal peptide since its primary structure position and hydrophilic profile do not follow the typical biochemical features of the classical transport sequences.
Upon EGF-stimulation, the relative phosphorylation of Y845 increased, exhibiting a clear dependency on the EGFR expression levels as well (elevated by ~ threefold for a ~ sixfold increase in EGFR), corroborating the autocatalytic function of Y845 (Shan et al., 2012).
Although transcription regulation factors are not included within the described protein classes of SFP across animals [ 63], AcpC04 meets the requirements to be considered an SFP; therefore, further genetic studies may corroborate the biological function of this protein in tiger beetles.
Our results corroborate the structure-function relationship where icosahedral CPMV particles showed significantly enhanced lymph node transport and retention, and greater uptake by/activation of APCs compared to filamentous PVX particles.
