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In the local frame of each module, the rest position (no chamber is inflated) corresponds to the module aligned along the vertical axis e 3, with a rest length L 0, see Figure 6 -left.
The gene expression matrix of the I-th module is denoted by X(I ) = (x i l (I ) ), where the index i = 1, 2,..., n I corresponds to the module genes and the index l = 1, 2,..., m corresponds to the microarray samples.
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Optionally, a higher level hierarchical representation of the network can also be created, where the nodes of the higher level correspond to the modules of the original network, and the links of the higher level correspond to the overlaps between the respective modules (Figure 1D, Figures S1.2 and S1.6 in the Electronic Supplementary Material S1).
The colors of the dynamic tree cut correspond to the modules assigned for each gene.
To verify whether the dense domain at the base corresponds to the Tail module, we characterized the Head + Middle modules assemblage by taking advantage of a Med16 Δ mutant in which the Tail module dissociates, and then compared the structure with that of the core Mediator.
We find that the resolution of a grid module is related to the packing ratio of L —the lattice with highest packing ratio corresponds to the grid module with highest resolution.
This procedure has been implemented in the CAPRA-GIS program, which corresponds to the risk module of the CAPRA platform, in the case of the water and sewage network, and the R System (ERN 2014), in the case of the portfolio of buildings.
The transparent yellow segment corresponds to the Mot1NTD TBP NC2 module.
That is, this mechanism also corresponds to the merging module mechanism [ 34], which induces hierarchical modularity.
The model reveals three distinct regions: a longer domain with an overall shape similar to that of the N-terminal NDF domain, a middle one presumably accounting for the 81 residues of the HLH motif (sequence 135 217), and a third one which probably corresponds to the KH1 module.
The novel combination algorithm comprises two kernel subalgorithms: The subalgorithm of Hausdorff-based RC corresponds to the pattern classification module, and the subalgorithm of IESIL works as the feature extraction module.
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