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For each of the latter, we fit the candidate models defined in Table 5 to the fitting set, i.e. the first 33, 40, 47, 53 or 60 values, and subsequently use them to make predictions corresponding to the validation set, i.e. the next 17, 20, 23, 27 or 30 values respectively.
For the four clinical experts (CE) sensitivity/1-specificity pairs were obtained (corresponding to the validation of ANN/MLR), ranging from 0.68/0.29 to 0.98/0.83.
This gene-expression data set was collected from 83 patients corresponding to the training data set and 17 patients corresponding to the validation data set.
A list of 39 driver fusions, the majority of which are more recent than ChimerDB2.0, and corresponding to the validation set used in [ 27], is adopted as the positive validation set examples.
FISH was assayed on 4 μm sections of Tissue-Micro-Array (TMA) of formalin-fixed paraffin-embedded NBT samples corresponding to the validation set, and partially matching the MSKCC series described above.
Analysis is to be conducted in two parts: an interim analysis corresponding to the derivation part of the study, and the main analysis corresponding to the validation of the derived cutoff algorithms.
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The "pooled" population (n = 652), corresponding to the "scoring and initial validation" population subset combined with the "robustness" population subset, was used to determine the PACT-Q psychometric properties.
The test-retest reliability of PRWE-Swe was found to be good with an intraclass coefficient corresponding to the findings of the original validation of the PRWE [ 13].
For the validation purpose, results corresponding to the perfect bonding assumption are compared with the experimental data.
With each validation process, corresponding to the other four runs, we were able to improve precision, while run 1 also improved the F-measure of the CEM task by 4.6% on the test set.
Following the observations and arguments described above we proceed to integrate in "three-dimensions color plots" the data corresponding to the values of correlation (r), cross-validation (N) and PPV obtained with each method.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com