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Scores corresponding to essential effects are in bold.
As commented above, the data consists of knock-out and hypomorph experiments, with the latter corresponding to essential genes [ 16].
To backtrack the necessary constraints (NC, corresponding to essential parameter changes), to original parameter characterizations, we counted the total number (out of n pert) of perturbations of which have a mapped effect such that the necessary constraints (equations (24,25)) are violated.
To determine whether it is necessary to control for gene essentiality, we assess whether there is a significant difference in helix/strand density, contact density, or the evolvability index in proteins corresponding to essential versus nonessential genes (supplementary fig. S8, Supplementary Material online).
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In this model, knock out of biomass production (and thus growth and survival) corresponds to "cutting" flux through at least one of the sinks corresponding to an essential biomass component.
d, Comparison of the ADaM core fitness genes with two previously reported reference sets9,10 of essential genes in terms of number of genes, estimated precision and recall (the genes included in reference gene sets corresponding to cellular essential process were considered to be true-positive genes).
The conserved aspartic acid residues within the LEF-9 motif, corresponding to those essential for activity of the Escherichia coli RNA polymerase largest subunit, were required for late gene expression.
Open image in new window Fig. 5 The primitive values of ( u_{0} ) which are corresponding to the essential condition for the formation of IA double layers, where ( sigma_{c} = 0.05 ), ( sigma_{h} = 0.2 ), ( H = 3 ).
Most origins contain multiple, imperfect matches to this motif with the best match not necessarily corresponding to the essential ACS.
Over the past 25 years, thousands of lethal alleles corresponding to >500 essential genes have been isolated.
Within each of the two resulting strata, corresponding to either essential or nonessential genes, we analyzed the relationships between HI and each gene property.
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