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The ADGPP and ASGPP are given by (19) and (20), respectively, with the corresponding substitutions.
The corresponding substitutions in Pla encoded in plasmid pMRK110 gave a protein with very low plasminogen activation.
Each SAR-TS-RP represents two compound series with different core structures and pairwise corresponding substitutions that yield comparable potency progression against a given target.
Alternatively, two different compound series with corresponding analogs, i.e., series having different core structures and containing compounds with pairwise corresponding substitutions, might display similar potency progression against a given target.
Single or double mutations of E829 and E832 to lysine or alanine showed similar, albeit less pronounced, effects as the corresponding substitutions in Fes (at E469 and E472), and the activity of an EE/KK mutant was restored by further substitution of E for R969 (EER/KKE), equivalent to R609 in the Fes kinase αC helix (data not shown).
Clearly, in order to evolve the constant character c:= c1⋯ c1 on a tree with root state c1, the corresponding operation would be σ ~ : = σ 0 ⊗ ⋯ ⊗ σ 0. Note that σ(c)= h and σ(f)= f d, and that two character states in hare identical if and only if the corresponding substitutions in σ are identical, too.
Similar(54)
Furthermore, we have extended the concept of MMPs to matched molecular series, i.e., analog series with different molecular core structures but corresponding substitution patterns [5, 6].
Adsorption mechanism illustrated that Cu was selectively adsorbed from the lixivium due to its strong coordination ability with amine groups on the sorbent surface and the corresponding substitution reaction (between Cu and the co- ions).
This suggests that corresponding substitution of an azulene is not obstructive to π⋯π stacking formation and may even be used for a potential pattern design of azulene dimers in a crystalline material.
To support this process, we have developed a data mining method that, for the first time, enables the identification of alternative analog series with different core structures but corresponding substitution patterns and comparable potency progression [1].
As expected, closed-form formula (26) reduces to (21) (applying the corresponding substitution of indexes) when the threshold value in the cross-link is set high enough to guarantee a continuous transmission in the interfering femtocell (i.e., when γ ̂ th → ∞ ).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com