Three series of new trifluoromethyl substituted quinolone derivatives were synthesized (4a f, 6a f and 8a f) from corresponding substituted anilines by multi-step reactions.
These 1,4-dihydropyridines were also photocatalytically oxidized by PHIK BM to the corresponding substituted pyridines, with very good yields and under mild metal-free conditions.
Deuterium incorporation experiments were performed, in order to investigate the mechanism of the bioreduction: the formation of the corresponding substituted 2-benzylacrylaldehydes, as intermediates to be effectively reduced by Baker's Yeast, was suggested.
The reaction of bis-pyrimidine (intermediate-II) with corresponding substituted aldehyde resulted in the formation of title compounds (q1 q20).
By Vilsmeier-Haack's reaction, starting from these sydnones we obtained the corresponding substituted 3-phenyl-4-formylsydnones in 17‒50 % yield (Scheme 1).
The compound 9 underwent nucleophilic addition with benzylidenemalononitrile in refluxing ethanol in the presence of piperdine afforded the corresponding substituted pyridine derivative 11 in good yield.
The typical process for these nicotinamide-based diamides derivatives is shown as following: To a solution of newly prepared intermediates 3 (1 mmol) in 8 mL of anhydrous acetonitrile was added the corresponding substituted amines (5 mmol) under nitrogen atmosphere.
The reaction of bis-pyrimidine (II) with 2-chloroacetyl chloride resulted in the formation of III {N,N′- 6,6′- 1,4-phenylene bis(4-(4-nitrophenyl)pyrimidine-6,2-diyl))bis(2-chloroacetamide)} which on reaction with corresponding substituted aniline yielded the title compounds (1–20).
By comparing the transcripts longer than 3.0 kbp with the ESTs contained in the PnFL2 library, we found 631 corresponding substituted CDS.
The corresponding substituted 3,3-diallyl-2-hydroxyindoline compound was added to a refluxing solution of first generation Grubbs' catalyst (15 mol %) in CH2Cl2 (ca. 0.04 mol L−1) under argon.
Interestingly, the parent phenyl compound 21 showed only a marginal increase in activity (45 μM vs. 62 μM), while the corresponding substituted phenyl ester 22 exhibited a 4-fold increase in activity over the parent methyl ester 1, demonstrating the importance of substituent effects on the aromatic ring.
