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For example, the activity of topotecan, irinotecan and SN-38 against cancer cell lines was shown to differ from their activity against corresponding primary samples (Jonsson et al, 2000).
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CRCLM samples were obtained from all patients, and from 234 patients the corresponding primary CRC samples were also collected.
In the present study, we found the FOXO4 expression in non-tumorous tissues was consistently stronger than that of the GC samples, and GCs showed a lower expression level of FOXO4 in metastatic lesions compared to the corresponding primary tumor samples.
These variants were detected in sequencing data from both blood and corresponding primary tumor samples confirming they are indeed germline.
This finding was further supported by detection of the identical BAP1 mutations in tumor xenografts, and the corresponding primary tumor samples and primary cell cultures (Table 3).
We performed immunohistochemistry of β-catenin, CK7, and CK20 in 19 lung metastasis of colorectal cancer samples, 10 corresponding primary colorectal cancer samples and 11 primary lung acinar adenocarcinoma samples and compared the levels of accuracy of the discriminating diagnosis by using antibodies against these antigens.
For 14 patients the corresponding primary and nodal metastases samples were available.
The comparative analysis between MSP from washout cells and corresponding primary and/or recurrence tumor sample was done for RARB and RASSF1A genes, including 23 urinary bladder washings and 39 paraffin-embedded UC samples from 20 patients (median age of 68.65, ranging from 42 to 84 years).
This study was approved by the Ethical Committee of the Medical University in Lublin (KE-0254/131/2011).> Formalin-fixed, paraffin-embedded (FFPE) tissue samples from 143 CNS metastases and 32 FFPE samples from corresponding primary lung tumours were collected.
Matsumoto et al. [ 14], examined 21 metastatic brain tumours from 19 NSCLC patients (68%% smokers) and eight samples from corresponding primary lung tumours.
All assays for the detection of seasonal influenza viruses were validated on approximately 80 100 primary samples containing the corresponding types and subtypes.
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