All outcome measures are compared between the two treatment groups using an ANCOVA model including factors for treatment, investigative site, and baseline A1C stratum (≤8.5% or >8.5%), and baseline values of corresponding outcome measure as a covariate (5).
For outcome measures of the stroke patients (ie, MBI, MMSE, SSES, and GDS), group (intervention and control), time of measurement (4 months and 1 year), interaction between group and time, age and sex of the stroke patients, stroke type, household income, and the corresponding outcome measure at baseline were used as covariates.
For this purpose we compared AMOS diagnostic subgroups (A-cohorts) to all retrievable patient cohorts (C-cohorts) with corresponding diagnoses, outcome measures and follow-up periods.
The author of the included trial (Flores 2005) did not report the number of events in the intervention and control groups for the dichotomous outcomes, therefore we calculated the number of events using reported per cent values and the number of participants in whom the corresponding outcome was measured.
Parental prevalence for the corresponding child outcome measure was included in models of asthma, eczema and hay fever.
We conducted a systematic review, comparing these five cohorts (A-cohorts, 392 patients from 90 medical practices, enrolled up to 31 December 2005) to all retrievable patient cohorts (C-cohorts) with corresponding diagnoses, outcome measure (SF-36), and follow-up periods.
Morbidity counts or rates were usually used as the outcome measures, whereas temperature measurements at corresponding intervals were employed as exposure indicators.
Assessor-blinded randomized controlled trials with sufficient power and carefully defined therapeutic components corresponding with objective and subjective outcome measures are recommended for future trial designs.
Table 1 displays the outcome measures and corresponding timepoints.
Analyses of treatment effect were by linear regression for numerical outcomes, or logistic/ordinal regression for any categorical outcomes, adjusting for the following baseline covariates: age, sex, pain intensity (primary outcome measure), and corresponding baseline value for secondary outcome measures.
