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Therapies designed against individual types of lymphoma often target features that differ between malignant cells and the corresponding normal cells from which they arise.
To identify genes encoding putative secreted or cell-surface proteins in human blood/serum/plasma as potential cancer markers, all genes overexpressed in the extracellular environment of cancerous cells relative to that of corresponding normal cells were filtered and retrieved from the Oncomine database and then imported to and analyzed by the biomarker module of the IPA analysis program.
The gene expression pattern in tumor cells differs from that in corresponding normal cells.
Through the microdissection technique, we selectively procured tumour cells and corresponding normal cells from histological sections of the 164 NHLs.
There are no reports of colXI α1 expression in cancer cell lines compared with corresponding normal cells.
Colon and breast cancer cells were more sensitive to MLL4 knockdown in comparison with the corresponding normal cells.
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Genome-wide methylation and expression data for 14 clear cell carcinoma (CCC), 32 non-CCC and four corresponding normal cell lines were generated to determine how methylation profiles differ between cells of different histological derivations of ovarian cancer.
Expression of colXI α1 was detected in all nine HNSCC cell lines examined compared with the corresponding normal cell line, which did not express colXI α1 transcript.
Surprisingly, we find that the propensity to become demethylated in cancer is not correlated with localisation to the nuclear periphery in the corresponding normal cell types.
Through parallels with the normal development of the corresponding normal cell types the CSC model can help describe the earliest steps in the tumourigenic process before a fully malignant tumour is formed.
Pretreatment of cells with ultrasound (20 kHz, 2 W cm−2, 60 s) selectively induced cytotoxicity in skin and prostate cancer cells, while having minimal effect on corresponding normal cell lines.
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