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The corresponding dose threshold is determined by the LET of the bombarding radiation.
*P < 0.05 vs. the corresponding dose in the control curve; # P < 0.05 vs. the corresponding dose in the curve obtained after saline; n = 5 for each group.
*P < 0.05 vs. the corresponding dose in the vehicle curve; # P < 0.05 vs. the corresponding dose in the reserpine curve; n = 5 for each group.
*P < 0.05 vs. the corresponding dose in the vehicle curve; n = 5 for each group.
*P < 0.05 vs. the corresponding dose in the control curve; n = 5 for each group.
*P < 0.05 vs. the corresponding dose to (R -isometheptene; n = 6 foR -isometheptene
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The MTT assay showed the corresponding dose-dependent decrease of cell proliferation and survival of cells, and the Western blot analyses confirmed that Vpr was produced in those Adv-Vpr-infected cells (Figure 3A b).
EphB4 siRNA lead to a corresponding dose-dependent reduction in EphB4 expression levels in Hoc-7 cells as well (data not shown).
Taken together, the dose-dependent depletion of mitochondria and the corresponding dose-dependent increase in abnormal morphology implicate a mechanism of mitochondrial toxicity.
We observed a dose-dependent downregulation of Bcl-2, Bax, Bad and XIAP upon GSI1 treatment and a corresponding dose-dependent activation of caspase 3/7 in MDA-MB-231 cells (data not shown).
One of the main objectives of this project is to summarize and evaluate the current knowledge on dosimetry and the corresponding dose-related risks when administering radiopharmaceuticals for diagnostic purposes in children and adults.
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