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Nine fluids did not have a corresponding blood sample analyzed.
By comparing the DNA profile of blow to the DNA profile of its corresponding blood sample, we were able to demonstrate that DNA extracted from blow did not lead to problematic microsatellite amplification, such as non-specific amplification and allelic dropout [14].
FISH may be preferred by pathologists as tissue characteristics are retained and no corresponding blood sample is required.
In this report, we describe findings for 954 individuals who completed the full study assessment and corresponding blood sample collection at both baseline and 18-month follow-up.
Comparing the results of CTLA-4 SNP genotyping in the tumor tissue and the corresponding blood sample, a shift from one genotype to another in more than 60% of patients was observed, for both studied CTLA-4 polymorphisms.
The corresponding blood sample of one patient after CHT was planned to be analyzed with the same method used for the sample before CHT (blue and red cohort in Figure 1).
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In DNA from corresponding blood samples of these patients the frequency was 57%.
Tissues and corresponding blood samples of the original study were taken with written informed consent from donors.
Importantly, sRAGE levels in the synovial fluid of RA patients (379 ± 36 pg/ml) were lower than in corresponding blood samples and correlated significantly with blood sRAGE.
The PRP was leukocyte-poor with an average of 2,5 × 10 platelets/ μL and a 3 times higher concentration of thrombocytes compared to the corresponding blood samples.
Two patients, one in each group, had a germline silent mutation in TP53 (Arg213Arg rs1800372), which was confirmed in corresponding blood samples (Supplementary data).
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