Furthermore, the observed association with metformin treatment and gender confers complexity when making correlative interpretations of data employing plasma fibulin-1 levels.
Although caution must be used when correlative interpretations are made with low numbers of subjects, our finding that weight loss induced changes in GIP are related to changes in insulin secretion warrants further attention.
Thus, quantification of methylation levels is an important consideration for the identification of significant methylation events and the interpretation of correlative analyses.
While the arrays show promise for improving diagnostic capability in breast cancers, ascribing mechanistic interpretations to correlative data should be done with extreme caution.
Since the exclusion of auto-correlative effects is necessary for unambiguous model interpretation, the estimated cross-correlative parameters should reflect the true nature of underlying physical processes.
Although functional genomic methods have provided considerable advances to our understanding of gene regulation, these assays, which are usually performed on a genome-wide scale, typically provide correlative observations that lack functional interpretation.
In such cases, the study interpretation must consider correlative endpoints to add, or subtract, toxicological "weight" to the observation.
YM collected the clinical outcome data for the in-house human breast cancer cohort and assisted in analysis and interpretation of clinical correlative studies.
The findings reported here highlight the importance of the cell context in the interpretation of predictive or correlative biologic readouts.
As VOCs were often correlated among each other, which would have obscured statistical and inferential interpretation [44], we used a simple correlative approach instead of e.g. a generalized linear model with all 15 VOCs concurrently as explanatory variables.
