We aimed to establish the safety and pharmacokinetics of avelumab in patients with solid tumours while assessing biological correlatives for future development.
While these observations are mostly correlative, recent technical developments allowing loss-of-function experiments and genome-wide approaches have permitted the identification of a causal relationship between specific changes in chromatin structure and the aging phenotype.
Combining light microscopy screening with a detailed EM analysis via tomography laid the foundations for the development of correlative microscopy-compliant protocols involving HPF and FS. 4.
This was addressed in our own original paper on the development of correlative video-electron microscopy (Polishchuk et al., 2000).
For this reason, and also for biochemical identification, a very important recent development is correlative cryo-fluorescence and EM.
Two subtracted cDNA libraries enriched in diapause- or development-correlative genes were constructed by using SSH.
Although the factors leading to extinction are complex, the cumulative impacts of industrial development are a correlative if not causative factor.
Arctic policy is conceived and implemented in two ways – first, in part by local government regulation, and second by The Arctic Council, the official body of nations with the most direct interest in the region, augmented by so-called observer nations, those not contiguous in their national claims but otherwise motivated by correlative opportunity, most especially economic development.
Future studies would likely benefit from patient accrual at both Eastern and Western sites concurrently, which would facilitate the performing of correlative studies critical to drug development.
Previous studies, based on the analysis of mutant and/or transgenic plants with reduced Sus activity, have demonstrated that cotton fiber and seed development are significantly correlative to the changes of Sus activity in ovule epidermis and endosperm [ 34, 54].
