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In the second, we apply Principal Component Spectral Analysis to separate correlations due to functional polymorphisms from those due to population structure.
It may simply originate from LD with a functional polymorphism.
When the detected polymorphism is in complete LD with the functional polymorphism, the favourable allele at the detected polymorphism can represent the favourable allele at the functional polymorphism completely.
Sst I polymorphism is located in 3′-untranslated 3′-untranslatedpoC3 gene, and it is possible that this polymoregion is in linkage disequilibrium with ofher functhenApoC3lymorphism in the nearby regene, such andT-455C polymorphitm.
This protective effect does not correlate with the known functional polymorphisms.
To assess the correlation between the density of functional polymorphisms (missense and nonsense mutations) and intronic burden, we used the dbSNP database.
Morphometry of intracellularly labeled neurons of the auditory nerve: correlations with functional properties.
Alternatively, the SNP might be in linkage disequilibrium with an unknown functional polymorphism.
The correlations could be due to functional polymorphisms or to population structure.
The absence of concordance between BAFF protein and mRNA regarding the correlation with BAFF polymorphism precludes any definitive conclusion regarding the functional role of this polymorphism.
Moreover, unlike many polymorphisms, the ACTN3 R577X polymorphism is a functional polymorphism, with the XX genotype resulting in complete loss of function.
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