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Exact(4)
The correlation of protection and the number of doses further supports the conclusion that the observed effectiveness is vaccine related.
The correlation of protection with low level virus neutralising gp70 antibodies only seen in a small number of vaccinated cats is an observation which has been reported previously.
By contrast, correlation of protection with serum IgA has been presented in mice following IN immunization with dl2/6-VLPs and cholera toxin [ 28].
Some studies have reported a dominance of serotype-specific neutralizing antibodies following natural infection, while other studies of naturally infected children found that the correlation of protection with neutralizing antibody titers was not serotype-specific.
Similar(55)
This study demonstrates a significant enhancement in the protective efficacy of BCG by over expression of Ag85C- an immuno-dominant antigen of M. tuberculosis and correlation of this superior protection with the immuno-pathological events attributable to modulation of the cytokine profile of pulmonary granulomas.
However, so far these have yielded diverse and inconsistent results showing varied correlation of levels with protection and pathology [ 84- 88], suggesting a delicate balance is required.
Identifying the degree of correlation of titers with protection against infection is also important for vaccine development, because annual reformulations of inactivated influenza vaccines can now be approved based entirely on immunogenicity data.
As participants were recruited at different times leading to varying exposure to infection relative to entry, a modified proportional hazards model was developed to account for staggered entry into the studies and to quantify the correlation of titers with protection against influenza infections, adjusting for waning in titers.
The correlation results are very similar to the ones above (Table 5): positive correlations between coverage and levels of protection are observed, with higher correlations for lower-income countries and almost no correlation for higher-income ones.
However, some studies show a negative correlation between the levels of protection and foreign investment.
These results should prompt an assessment of whether these antibodies exhibit neutralizing activity against HIV, or if the correlation with protection of target cells arises from other mechanisms.
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