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This clustering of loci and correlation of effects can be attributed to different linked QTLs occurring on the same segment or pleiotropic effects of a single QTL.
The similarity of ethanol yields between compounds representing cluster 1, acetate and glycerol yields in cluster 2 and the strong correlation of effects of vanillylidenacetone and Gallic acid (cluster 3) on ethanol, glycerol, acetate and biomass yields suggest that compounds belonging to the same cluster have similar inhibitory activity on yeast.
A significant correlation of effects of ClO4− with serum thyroid hormones in humans has yet to be confirmed, so the importance of this potential MOA in humans is not known.
Indeed, in the example presented above, although the correlation of effects estimated by BRR and BayesB was low (0.226), the correlation between predictions (yHat) derived from each of the models was relatively high (0.946).
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Correlation of effect sizes for non-HLA SNPs in GWAS meta-analysis was analyzed between ACPA-positive and -negative RA, -negative RF-positive or -negative RF-negative RA by Spearman's correlation coefficient for SNPs pruned by r <0.3 by PLINK with intervals of P-values.
Additional file 4: Strong correlations of effect sizes in single nucleotide polymorphisms (SNPs) between analyses with or without age and sex as covariates.
Varona et al. [ 12] suggested that the SNP effects could be modeled assuming that there is a genetic correlation of SNP effects across breeds.
Choi, O. H., Shamim, M. T., Padgett, W. L. & Daly, J. W. Caffeine and theophylline analogues: correlation of behavioral effects with activity as adenosine receptor antagonists and as phosphodiesterase inhibitors.
Here we propose a new natural measure of the amount of epistasis based on the correlation of fitness effects of mutations.
Furthermore, the dependence of the correlation of fitness effects on mutational distance contains interesting information about the patterns of epistasis.
The two-dimensional applications discussed in this study could be immediately extended to three-dimensional cases by appropriately accounting for the spanwise correlation of aerodynamic effects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com