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The observation concerning "functional polymorphism without speciation" is interesting, but it is not clear why it is buried in an additional file.
In the second, we apply Principal Component Spectral Analysis to separate correlations due to functional polymorphisms from those due to population structure.
Indeed, our study underscores how much remains to be discovered concerning the role of functional polymorphisms in cognitive function and the need for further research in order to fine-tune useful clinical intermediate phenotypes that affect high-level information processing.
Moreover, unlike many polymorphisms, the ACTN3 R577X polymorphism is a functional polymorphism, with the XX genotype resulting in complete loss of function.
A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition.
Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.
Xu, Y., Goodyer, C. G., Deal, C. & Polychronakos, C. Functional polymorphism in the parental imprinting of the human IGF2R gene.
Miyamoto, Y. et al. A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis.
The second polymorphism is a 44-bp insertion/deletion functional polymorphism in the promoter region known as 5-HTTLPR.
The ACTN3 R577X (rs1815739) polymorphism is an exception in this sense, since it is a well-studied functional polymorphism.
A functional polymorphism in the HTR2C gene associated with stress responses: a validation study.
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