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To compensate for small sample size, we exploited the many-to-many network of miRNA targeting relationships to create a differential mutual concordance score (see details in Methods) and thus identify the miRNA-target mRNA pairs exhibiting the highest correlation change between AD and control.
Does the correlation change if the arbitrary log2 cut-off of 1.6 is changed?
The vertical distance between each data point and the diagonal (equality line) indicates the correlation change.
Further investigation revealed the dynamic correlation change patterns of each cluster.
However, the extension of such gene-pair measures to the pathway level allows the identification of pathways that show, e.g., a condition specific correlation change.
A correlation change for each pair of probe sets was visualized by using a line plot with 11 data points, as in Figure 1, where the 11 data points correspond to the number of correlations considered in this study.
Similar(42)
This is confirmed by using order correlation changes along these directions measured by WAXD experiments.
Therefore, the correlation changes with the change in the elative positions of the source and the sensors.
First, we observe that for some metrics, the correlation changes over the years, while for others, it remains constant.
We consider correlation changes while magnetosheath satellite approaches the magnetopause and do not find correlation dependence on the satellite position inside the magnetosheath.
It shows that the variance of the projected data had a broad profile, which is evidence that the patterns of correlation changed progressively across target direction.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com