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The correlation averages 0.74 over 12 unrelated families of transcriptional regulators, including nuclear hormone receptors, basic helix loop helix, ETS- and homeo-domain family.
Over the entire five-year period shown in the chart, the correlation averages out to -0.1, indicating a fairly weak, slightly negative relationship.
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Therefore, the positive correlation average masks distinct populations of positively and negatively correlated miRNA-target pairs, and it is the relative abundance of positive and negative correlations that drives the average.
Saxton, W. O. & Baumeister, W. The correlation averaging of a regularly arranged bacterial-cell envelope protein.
The measures of eccentricity and contour smoothness were adapted from literature, the other five being triangle heights, triangle perimeters, rotation correlation, average orientations, and ellipse axis ratio.
Diamond shape = overall correlation average across listed studies on graph.
Hierarchical cluster analysis (Pearson correlation, average linkage) was performed using Genesis software suit [ 90].
The interclass correlation (average measure) between the two observer's scores was 85%.
Final predictions used absolute value of correlation averaged over three runs.
In comparison, when using the previous TFBS predictions, we found a lower average correlation (average Pearson's R = 0.203).
This also resulted in the within-subject correlations being larger (average r = 0.90) than the cross subject correlation (average r = 0.77) for all HIV-infected subject samples.
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