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Taken together, these data suggest that Fra activity is required to correctly regulate Abl-dependent cytoskeletal dynamics underlying commissure formation.
In the normal network, input molecules correctly regulate the output molecule.
Insulin resistance occurs when increasing amounts of insulin are required to correctly regulate transport of plasma glucose into peripheral tissues.
These data confirm that the 10.5 kb transgene contains sufficient information to correctly regulate GM-CSF gene expression in a position-independent and copy-number-dependent manner.
Hence, it appears equally important to balance levels of both positive and negative input to correctly regulate the periodicity of clock gene oscillations.
These results demonstrate that the 874 bp apRXa wing enhancer element is required but not sufficient in the endogenous context to correctly regulate ap expression.
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Furthermore, AmphiVent1 and AmphiVent2 promoters appear to be correctly regulated in the context of a vertebrate embryo.
A view is therefore emerging to suggest that sterols are required for correctly regulated auxin signalling, by mediating carrier protein localization or functionality in the membrane.
This promoter fragment stretches 641 nucleotides upstream of the cycC coding sequence to the terminus of the neighbouring gene, and is therefore likely to contain all the elements required for correctly regulated cycC expression.
Taken together, our data suggest that the AmphiVent1 promoter is correctly regulated in the vertebrate embryo and that its spatiotemporal activity is by large similar to the activity of Xvent-2B promoter in the same context.
Finally, when optimising for phase imaging and/or when the feedback amplitude is not correctly regulated, images obtained by acquiring the amplitude error signal, commonly referred to as amplitude imaging, also revealed topographic features with high lateral resolution but without any three-dimensionality.
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