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Second, we used the method of Net Reclassification Improvement NRII) 32, 33 to examine whether adding this particular variable could correctly reclassify participants into appropriate categories.
NRI measures the ability of a new model to correctly reclassify patients without the outcome of interest (i.e. death) into lower risk categories and patients with the outcome of interest into higher risk categories.
The reason for such a methodological choice relies on the fact that we were interested in building a predictive model that, by definition, is expected of significantly capturing the contribution of predictors that correctly reclassify subjects according to their future outcome; it is of note that this is exactly what cNRI is able to guarantee.
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Figure 2B shows that of the 280 men who did have a cardiovascular event, 2 were incorrectly reclassified downwards and none correctly reclassified upwards when ASBP was included in the model.
In order to illustrate the improvement given by lactate in association with PCT, we provide a reclassification table that enables us to quantify the benefit of the association in terms of number of patients correctly reclassified.
The DFA correctly reclassified individuals, on the basis of temporal and spectral parameters of food calls.
RPA of NIRS amplitudes correctly reclassified 89% of patients [AUC: 0.91].
The addition of CTCS to Diamond & Forrester resulted in reclassification of 47.2% of patients of whom 73.3% were correctly reclassified.
RPA of the combined IPSS, prostate volume, PVR, and Qmax correctly reclassified 72% of patients [AUC: 0.84].
The proportion of events and non-events correctly reclassified (reclassified up and down, respectively) are adjusted by the proportion of events and non-events incorrectly reclassified.
During the CTP evaluation, 15 (37%) of 50 70% stenoses were correctly reclassified due to the normal rsCTP as nonsignificant; one stenosis was reclassified falsely.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com