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As mentioned in our overview of KiP, shifting to correctly prioritizing the Force as Deflector p-prim is key to understanding formal Newtonian relationships underlying Newton's first law.
Note that uncertainty in the set of causal genes that we use as reference set will lead to an underestimate of the performance of our method in correctly prioritizing fine-mapped genes.
We demonstrated that the two methods achieved significantly improved performance compared with previous methods in correctly prioritizing candidate diseases in all of the three sets.
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Pathogenic ncSNVs in promoter regions are most likely to be correctly prioritized by DeepSEA, GWAVA, and LINSIGHT, while CADD works better on prioritizing pathogenic ncSNVs in introns.
The most pressing issue now facing governments is choosing groups most at risk in their countries so that vaccinations are correctly prioritized when they become widely available.
A sound bankruptcy proceeding should do two things: productively redeploy the assets of the bankrupt firm and correctly prioritize various claims against the bankrupt entity.
We were able to correctly prioritize 67% (4/6) of the five genes known to be associated with JBTS as the first ranking candidate in a 6 Mb interval surrounding each.
Consequently, diseases of the eye that do not affect these tissues will not be correctly prioritized by our approach.
The percentage of correctly prioritized candidate genes (8/16, 50%) is much higher than the above mentioned percentage of genes that is prioritized using our approach (9%).
Only cases for which the candidate gene was correctly prioritized by our approach are shown, in combination with the biological processes involved.
An improved rank of the network score would enhance the possibility to correctly prioritize a disease gene, because it would increase its chance to be highly ranked among candidate genes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com