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In our PPI strategy, we attempt to correctly partition the portfolio into several similar sub-portfolios and then insure the sub-portfolios individually.
First, we used a NCI60 dataset to validate the ability of pathways to correctly partition samples.
We then tested if information integration would further enhance the algorithm's ability to correctly partition mixtures of genes.
We tested whether, for the given F-G pair, Mimosa can correctly partition a set of expression samples and detect the modifier M. For the expression data, we used 314 S. cerevisiae expression samples previously compiled in [ 14] from 18 different studies.
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Medium-complexity file formats are correctly partitioned, and the constant fields are extracted.
In the case of simulated data, sites were correctly partitioned, with branch lengths treated separately for sites in each partition.
Importantly, we have shown that CD-1 and ICR mice, which derived from the same outbred stock but have been isolated and maintained by two different vendors, were correctly partitioned into two subpopulations.
Quantigene analysis of the top 26 differentially expressed genes correctly partitioned cervix samples as SCC or AC.
In a simulation, which used real clusters combined randomly using a single identifier (see Methods), of 19,863 combined clusters, 19,258 cases were correctly partitioned.
No random subset achieved an ARI value higher than that of the corresponding pathway such that all identified signature pathways showed significantly better performance (P < 0.001) in correctly partitioning the samples (that is, more likely relevant to the phenotypic partitions).
The initial set of samples comprised a training set for which 22 of 23 samples were correctly partitioned into a cluster containing primary melanoma or the cluster containing MM samples.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com