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This guarantees that all merged reads that can be mapped to the reference genome are correctly merged.
This sequence is initially segmented into 6 regions, with 1 region corresponding to the actor, and the background divided into several regions, which are all correctly merged in the histogram- and trajectory-based merging stages.
However, overlaps that exclusively maximize f might not yield correctly merged sequences.
However, due to HMM, HEPeak correctly merged the two peaks into one peak.
With the exception of the first test case (no overlaps), PEAR consistently generates a larger number of correctly merged sequences when the statistical test is disabled.
If, however, the overlap is known to be short (35-bp in our simulations), our statistical test will reject up to 4% (based on our simulations) correctly merged sequences because of low quality scores.
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The technique achieved an average accuracy of 72% for correctly merging actions performed by different participants.
In practice, one is often confronted with non-stationary ambient excitation sources (e.g., wind, traffic, waves, etc).. Since the scaling of operational mode shape estimates depends on the unknown level of the ambient excitation, an extra effort is required in order to correctly merge the different parts of the mode shapes.
Due to the inconsistency of motion between the head and torso of the actor, the reference method's trajectory-based merging stage is unable to correctly merge all of the initially segmented regions.
PANDAseq correctly merges the highest amount of reads; PEAR ∼2% less (statistical test disabled).
The best competing merger (PANDAseq) correctly merges 83.51% of the fragments, but with a FPR of 6.65%.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com