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7) Monitoring and error correction will be performed by reviewing videotaped performance during the debriefing.
A one-way analysis of variance (ANOVA), with Bonferroni correction, will be performed to determine whether the ratio of VO2bike/VO2walk is affected by disease severity.
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In case of baseline differences of costs, effectiveness, or utility scores between the patient groups, corrections will be performed [ 77- 79].
A Bonferroni correction for multiple testing will be performed.
Descriptive statistics (means, standard deviation) will be calculated to summarise the data set for both groups and to identify potential baseline differences between the groups; p values will be used to indicate the strength of the evidence, and the Bonferroni correction for multiple assessments will be performed.
Corrections for multiple comparisons will be performed with Bonferroni or Dunn's test.
In its basic form (I think the one used in the protocol) the LSD correction is not taking into account that multiple comparisons will be performed and therefore a Bonferroni correction (or other corrections) must be employed.
For each chip, colour bias adjustment using quantile normalisation and background correction based on a negative control will be performed using the R-package lumi [ 66].
Resistive wall mode (RWM) control, error field correction, and edge-localized mode (ELM) control will be performed using in-vessel coils.
When correction for confounding variables is necessary, multivariate regression analyses will be performed.
Autopsies will be performed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com