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Pearson's Chi squared test with Yates' continuity correction (where appropriate) or Fisher's exact test for count data were used for categorical data.
For count data, we applied the second-order correction developed by Rao and Scott [35], [36].
We provide an exploratory and a regression-based comparison of the innovation count data and data on patent counts at the lowest possible levels of geographical aggregation.
One possible contribution to this is inadequate dead-time correction of data at high count rates.
Gene count data and software used for correction of gene length bias associated with nuclear RNA is available at genome-tech.ucsd.edu/public/sNucSeqNorm. Funding support for KZ and JC was from the NIH Common Fund Single Cell Analysis Program (1U01MH098977).
Alternatively, the less conservative Holm correction was applied for the correction of the data [ 24].
The bivariate meta-analysis itself used the 2 × 2 count data without the +0.5 correction for zero counts.
Data were normalized by spatial correction of the raw data.
This program controls for library size, models the count data with a negative binomial distribution, and identifies significantly DE genes after a Benjamini-Hochberg correction for multiple testing and a threshold of an adjusted p (padj) < 0.05 [ 51, 58].
CD4 cell count data could help to exclude some individuals with long-term infections but, in addition to the logistical challenges of doing this, the variability in CD4 counts within and between individuals [40] would make such a correction technical involved and likely incomplete.
For similar reasons, overt aggression count data were summed across spawn periods and phases and analysed with the Wilcoxon signed rank test with continuity correction.
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