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If the overall F statistics from the one-way ANOVAs were significant at the alpha = 0.05 level, paired group comparisons were performed with a Bonferroni correction for multiplicity.
One trial [39] used a correction for multiplicity proposed by Peto [52] et al and Geller [53] et al with a significance level of <0.001 while the other trial [45] used a two-step stopping rule when the between group difference in ICU mortality was ≥20% with at least 45 patients in each arm.
No correction for multiplicity was done.
No correction for multiplicity was made.
Nominal p-values are reported without correction for multiplicity.
Each interaction was tested individually without correction for multiplicity.
Similar(25)
All the above corrections for multiplicity of comparisons are conservative and assume that the tested SNPs are independent, while this is an oversimplification.
In addition, no corrections for multiplicity were applied as this is an explorative study.
However, only the associations for ADHD and ADHD-I retained significant after corrections for multiplicity or logistic regression analyses adjusting the potential confounding effect of gender and age.
Even with well-matched, coherent phenotypes, the specter of underpowered statistics due to corrections for multiplicity remains a very real problem [ 4].
We therefore assume independent survival of the cells in the microcolony and have applied corrections for multiplicity for T-47D cells.
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