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TF maps were again calculated with the non-uniform Chang algorithm from these altered attenuation maps and then used for correcting for attenuation in their corresponding SPECT images.
Pourmoghaddas et al. reported relative errors of 5% ± 3%[47]] when correcting for attenuation and scatter [20] for a similar measurement setup.
For PET-CT, it has been shown that MBF can be measured accurately with 15O-water without correcting for attenuation [21].
PET images were acquired using either the high-resolution research tomograph (HRRT) or the FOCUS 220 scanner (Siemens/CPS, Knoxville, TN, USA) for 120 min in 33 frames, with frame durations ranging from 30 s to 5 min, and correcting for attenuation and scatter.
Correcting for attenuation is an essential requirement to perform an accurate quantitative analysis of PET data.
It is also possible, though not uncontroversial, to control error statistically by correcting for attenuation using validation data [ 24].
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Because liver data across all subjects were not corrected for attenuation, an attenuation correction factor was included as a parameter in the model and estimated to scale counts/s data to activity in nCi/g liver (Table 2 ).
Top row images are reconstructed without attenuation correction (AC); bottom row images were corrected for attenuation.
All SPECT data were corrected for attenuation by CT-attenuation correction through a low-dose spiral CT scan performed directly after acquisition of the emission data.
Images were corrected for attenuation and reconstructed in 3D [23, 23].
Finally, the 2D planar image is corrected for attenuation.
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