In typical microarray experiments, quantified spot intensities are corrected with a local background value based on the intensities of pixels just outside the spot area.
"I am very confident that the legal advice from our staff is correct, that a local law would be needed to withhold and not give this year's rebates," Ms. Quinn said on Thursday.
Time-series data were modelled using a general linear model (FILM; FMRIB Improved Linear Model), correcting for local autocorrelation (Woolrich, Ripley, Brady, & Smith, 2001).
MicroRNA levels were expressed relative to wild-type levels, correcting for local and systemic background signals.
After the binding signals were further normalized by correcting local background signals with a 9 × 9 sub-grid, Z-scores of each protein on the array were determined as previously described (Hu et al., 2009).
It is thus likely that in these 17 cases, the overall construction of the contig was correct except for a local mis-insertion of a single alien BAC.
Given that some false positive predictions may be correct (due to the paucity of crystallized complexes), patch-specific performance metrics (i.e. assessing the correct answer in a local patch around an interface in question, such as by the Sørensen-Dice index [ 253, 254]) may be used, though this poorly accounts for false positives.
We considered these 14 SNPs in a recessive risk inheritance model, corrected for local and global ancestry, and applied a false discovery rate (FDR) multiple comparison correction to their P-values (17).
The same protocol was applied to cells expressing free Dam proteins and the sequencing data served as a control to correct for local DNA accessibilities [ 27] and sequencing biases.
All arrays were background corrected using local background correction and normalized using Lowess normalization [ 87].
