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The manuscript was revised for typographical error was corrected where applicable.
In addition, gene models that had alternative model predictions which were longer were explored using InterProscan5 and manually corrected where applicable.
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Electrolyte abnormalities were corrected where possible.
All these algorithms suggest that many features of models already in the PDB are likely wrong, but no automated mechanism currently exists to decide if a better modeling of specific areas would be better consistent with the validation criteria, correct these errors where applicable and make the new, corrected models available to the user community.
Although the trend for antibody-independent assays is on the rise, demand for consistent performance of antibodies (both in choice of antibody and how to apply it in the correct dilution where applicable) in immune assays remains unmet in too many cases.
Microarray datasets were preprocessed by RMA and, where applicable, corrected for batch effects by ComBat, as described in Methods.
The Bonferroni method was used to correct for multiple comparisons where applicable.
One-way ANOVA was used for direct comparisons, correcting for multiple variables where applicable.
Where applicable, non creatinine corrected data were corrected using the U.S. population mean creatinine value of 1.38 g/L for ages 30 39.
Where applicable, the corrected free energy differences will be shown in parentheses.
PCA was performed on the z-scores of the behavioural variables described above computed after data transformation (where applicable) to correct normality.
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