By application of BCTI to the validation of IHC, operator bias and therefore poor reproducibility can be identified, characterised and corrected to achieve a level of error normally associated with a quantitative biomarker assay, such as an ELISA.
Densitometric quantitation was performed as previously outlined and results were corrected to GAPDH levels, used as a housekeeper, to correct for potential errors in loading.
When correcting to the 50% level, an SRT of −23.1 dB and slope of 12.1%/dB was found.
When tested against experiments, the predictions of the Standard Model "turned out to be correct with a level of precision which is astonishing," Dr. de Rujula said.
The physician may simply rely on diet and the body's ability to correct a low potassium level naturally, by eating foods that are high in potassium.
The statistical tests were corrected for multiple comparisons to a significance level of P < 0.05 using Monte Carlo simulations (uncorrected single voxel significance level of P < 0.05 and a minimum cluster size based on the size of the GM mask of each load).
The tested results were corrected for multiple comparisons to a significant level of P < 0.05 (Bonferroni correction across the five frequency bands).
Six different instruments were used for analysing construct validity, leading to a corrected level of significance of α = 0.05/6 = 0.0083.
Unfortunately, 2 months later, the serum calcium concentration increased again to a corrected level of 3.9 mmol/L and the patient suffered from nausea and vomiting.
All the statistical maps were corrected for multiple comparisons to a significant level of P < 0.05 (bilateral) by combining the individual voxel P value <0.05 with cluster size >2079 mm based on using Monte Carlo simulations [ 25].
