These results reveal that WM deficits with aging cannot be corrected solely by remediating age-related perceptual impairment, but perhaps by also targeting interventions at other processes supporting WM, such as memory maintenance.
This variation could be mainly caused by a bias in the MNase treatment, PCR amplification or sequencing, which cannot be corrected solely based on a computational method.
These methods included Fold Change, difference after transformation, T without (correcting solely for intensity, eq. 3), T-score (correcting for intensity and probe set-specific variability, eq. 4), and Cyber-T, a t-test based method that combines the empirical variance of a replicate set with the local background of intensity-dependent variance[ 15].
As for the ACSC databases, phantom calibration was instrumental in compensating for partial volume losses in BRASS (~67%, p < 0.001), while for the Southampton method, inherently free from them, it brought no significant changes and solely corrected for residual inter-camera variability (−0.2%, p = 0.44).
Several authors have, therefore, proposed to infer bias corrected estimates based solely on the initial sample data.
Therefore, our expression data were inserted in the PCA as raw data solely corrected against the reference genes but not against any control groups of the underlying cell culture assay.
The classical prophets did not reject all cults, per se; rather, they wanted a cultus ritually correct, dedicated solely to Yahweh, and productive of ethical conduct.
In this model the probability of a correct answer solely depends on the ability of the person and the difficulty of the item.
It has recently been shown that the phenotype of severe SMA mice can be corrected by expressing full-length SMN solely in the nervous system (14).
All spot intensities above 50 000 were corrected, ensuring that asymmetry in the distributions was caused solely by the scanner behavior at low intensities.
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