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Due to study limitations, the outcomes were corrected only for known important clinical risk factors, but not for other variables.
With the exception of SF-12 Physical, QoL values were corrected only for age, sex and education, because several of the scale questions are directed at investigating the presence of depressive symptoms.
Shown on the same table are results from the model corrected only for heterogeneity.
However, we did not consider enough to be corrected only for this method.
49 Direct non-medical costs were corrected only for differences in purchasing power.
However, the differences were similar if the pulmonary function values were corrected only for height (and not age).
Similar(51)
We used the PLINK/SEQ estimate of the smallest achievable empirical P-value for a gene (I-value) to adopt an adjusted Bonferroni correction for multiple testing, by correcting only for the number of genes for which there was power to detect association (I < 10− 3) (Kiezun et al., 2012).
a wt8_kal corrects for both, panel attrition and the disproportionality of the sample, basewt corrects only for the disproportionality of the sample.
One may note, however, that we find a significant effect if we applied a weight (basewt) correcting only for the disproportionality of the sample.
No additional associations were identified when correcting for both Q and K as compared to when correcting only for Q.
Finally, no significant enrichment was observed in the top 500 results from an EWAS performed correcting only for batch effects and estimated cell counts (see "Methods" section).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com