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Results of all tumors (corrected for stage) and separately for stage T1 tumors are shown.
Cancer location, corrected for stage distribution, did not influence detection of markers in blood (Additional file 3, p value = 0.555).
An ANOVA Chi-square test (R version 3.1.2) was performed on assay positivity rates corrected for stage distribution in proximal and distal cancers using a generalised linear model with a logistic regression model fitted to two covariate models including stage and lesion, or lesion only.
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However, when correcting for stage, age and gender there was significantly shorter DSS for patients with tumours staining strongly for STMN1 (HR=2.1, 95% CI 1.04 4.25; P=0.04) compared with those with negative tumours.
There was, moreover, no association between recurrence-free survival and telomere length (HR 0.94, p=0.87, Cox proportional hazards model) after correcting for stage, radiotherapy, chemotherapy, age and sex (details not shown).
The analysis showed that INSS stage and INPC histology were significantly and independently associated with patient survival (P=0.0002 and P=0.0051, respectively), and that the biological variables, MYCN amplification and DNA ploidy, did not have prognostic significance after correcting for stage and histology by the INSS and INPC.
Stage-specific RNA-Seq data were corrected for each stage by a correction factor (based on the amount of RNA per parasite nucleus present in each stage as described earlier [ 18]).
Vascular thromboembolic event is more common in advanced stages of cancer but confers a worse prognosis even if corrected for pathological stage.
The head drop across the wellhead choke, corrected for one stage, is calculated in metric units: {text{Drop}} = 0.3048, 2.3, left( {p_{text{wh}} - P_{text{downstream}} } right)/gamma_{text{l}} /{text{no}}.
They should either be corrected for the stage of pregnancy, or total thyroxine levels should be used instead for diagnosis.
However, the main finding from our study was that high levels of 8-oxo-dG were associated with poor survival, both in uncorrected analyses and when corrected for tumour stage.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com