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There was a similarity between the gender corrected effect size and the effect size when no gender was corrected for, especially in the Finnish sample (Table 1).
The "publication bias" corrected effect size attenuated to 0.07 (−0.02 to 0.16), and this was not significant (P = 0.117).
In the calculation of these extrapolation factors, we corrected effect concentrations for differences in test durations by using the mechanistic TKTD model.
For Bayesian normalization, features are ranked by the absolute value of the posterior mean of δ g, which is the winner's curse corrected effect size for each miRNA.
The uncorrected and corrected effect of the intervention on the primary and secondary outcome measures at 6 months will be assessed with logistic regression for categorical outcomes and linear regression for numerical outcomes.
Based on clinical judgement and after univariate analysis, we entered all parameters that could likely be associated with disturbed glucose metabolism in a logistic regression model, and assessed the corrected effect of those elements using bootstrapping.
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The corrected effects were 53% (30%to70%0%), 55% (25%to7777%) and 67%38%to86% 86%), slightly higher than the corresponding uncorrected values.
Clinical meaningfulness of differences observed was assessed by evaluation of the magnitude of the differences relative to clinical outcomes in the literature, and calculations of effect sizes (Formula 1) adjusted via Hedges bias-corrected effect size for small sample sizes [ 56].
We did not record the correcting effect of removal of osteophytes, but aimed at describing the effect of ligament releases alone.
Interestingly, some studies suggest that customized interventions might be implemented to correct effects on phenotypic changes [ 153].
Each time series was corrected for effect of head motion parameters by linear regression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com