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Protein degradation is the endpoint of gene expression, and correct turnover of proteins is essential for cellular function.
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These selected examples illustrate the importance of disordered segments for maintaining correct protein turnover.
If this is correct, muscle ATP turnover rates in type 2 diabetes could be increased if glycogen synthesis rates were normalized by the mass-action effect of hyperglycemia.
i) Even if the predictions are correct for the neutral turnover model, it is not clear that other models would not generate similar predictions.
If our hypothesis is correct, namely that bone turnover markers are associated with BMLs and that – like BMLs – they predict cartilage loss, then this will provide important insights into the pathophysiology of OA and may provide a biomarker that, like the BML that it reflects, may potently predict cartilage loss.
It is clear that the dissociation of the elongated product from the polymerase limits the multiple turnovers of correct nucleotide incorporation; however, there has been a long-standing debate over whether step 3 or 4 in Figure 2 is rate-limiting during the first turnover.
To maintain steady dermal collagen levels, it is important to correct changes in the protein turnover rate induced by UV irradiation.
In conclusion, we demonstrated that Lis1 plays a crucial role in cortical circuit assembly by regulating filopodia and spine turnover to establish correct connections and promote synaptic plasticity during adolescence in mice.
If assignment as CO was correct, it is puzzling that turnover did not occur; the authors attribute this to the low pH of the crystallization conditions which may have disfavored the deprotonation necessary for activity.
We thus corrected for differences in protein turnover that played a role in the experiments depicted in Figure 1, where untagged Bcl-2 proteins were expressed.
Therefore, high rate of bone turnover was well corrected by PME suggesting that it might play a protective role against ovarian hormone insufficiency related bone resorption.
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