Sentence examples for correct trafficking from inspiring English sources

The assays described in this report are designed specifically to identify compounds which result in the reactivation and correct trafficking of misfolded gonadotropin releasing hormone receptor and vasopressin type 2 receptor mutants, rather than those which act as agonists directly.

Loss of the helix-capping interaction in R165W may affect the correct trafficking of this receptor, providing a possible mechanism for the observed malfunction of this mutant.

This was associated with increased cone response and survival, suggesting that visual chromophore may act as a chaperone to improve sorting and correct trafficking of these proteins [16] [17], [49].

We speculate that the dodecameric structure of the SV40TAg:p53 complex [28] may be incompatible with the topology of the LOC and CAT fusions or that the high molecular weight complex interferes with correct trafficking of the Och1p fusion proteins, a phenomenon that was observed when another large oligomeric complex was ectopically localized to the secretory pathway [29].

In fact, residues surrounding the PEXEL motif were found to be important in correct trafficking or folding of exported proteins [9], [10], and a recent study suggests that the short pentameric core motif alone is insufficient to cause protein traffic across the PV membrane [11].

Correct trafficking of lysosomal enzymes requires posttranslational modifications [ 113].

Before jug handles and Jersey barriers, freeways and toll roads (not to mention EZ-Pass), cloverleafs and flyover ramps there was the majestic, geometrically correct traffic circle.

Under the power of the Harvard team's coded instructions, the Kilobots can work together to correct traffic jams and incorrect positioning.

Mutations of GALC that cause misfolding of the protein may be responsive to pharmacological chaperone therapy (PCT), whereby small molecules are used to stabilize these mutant proteins, thus correcting trafficking defects and increasing residual catabolic activity in cells.

The identification of trafficking-impairing mutations in CAMs associated with various neurodevelopmental disorders underscores the importance of correct protein trafficking for normal brain function.

Choudhury, A. et al. Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells.