Transient expression of GFP-myosin IIB corrected the impairment of lamellipodia formation by HeLa-Clontech cells (Fig. 1B and 1C).
Importantly, for patients with liver disease, the hyperintensive T1-weighted MRI signal in the basal ganglia is normalized after liver transplantation (Aggarwal et al. 2006) that corrects the impairment in Mn excretion.
However, in the in vitro system employed in the present study, 1mT is used to prevent HIV-induced tryptophan depletion rather than correct the existing impairment.
We demonstrated that a minimal concentration of CEppt is capable of inhibiting the formation of both Aβ toxic oligomer species and amyloid fibrils in both the test tube and in the intact animal, and can correct the cognitive impairment in AD animal models.
We therefore reasoned that Opa1 overexpression could be exploited to correct the biochemical impairment and mitigate the pathology associated with genetically determined OXPHOS failure in available mouse models of mitochondrial disease.
In order to estimate and compensate the effect of CFO and FTD and the interplay between these effects shown in (14) and (25) we propose a receiver to jointly estimate and correct the channel impairments subchannel-wise.
The patient and surgeon need to discuss if the potential benefits of surgery to correct the patient's current visual impairment are worth the small risks.
However, these mechanisms have been proposed to explain the recent observation that a pan-PPAR agonist, bezafibrate, was able to correct the COX defect, ameliorate motor impairment, and prolong life span, in MLC1F-Cox10 −/−, a mouse model characterized by muscle-selective ablation of Cox10, a heme a biosynthetic enzyme.
Monofocal IOL implantation allows either distance or near vision to be corrected, so patients with both problems still need to wear glasses to correct the one or the other visual impairment.
Initially shown to boost oxidative metabolism in diet-induced models of obesity, Parp1 ablation or inhibition has recently been reported to remarkably rescue pharmacological models of liver cirrhosis, partly by correcting the associated mitochondrial impairment (Mukhopadhyay et al., 2013).
