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Wouldn't it be more productive to examine the bulletproof vests and learn how to correct the deficient ones?
There is growing consensus that indirect measures to correct the deficient proteostasis of CFTR may be fruitful.
Inhibition of lysosomal proteases has been shown to increase intracellular cytokine levels in HkEc-stimulated human MDMs and to correct the deficient levels found in cells from CD patients (Smith et al., 2009).
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Therefore, CF patients would strongly benefit from pharmacological compounds combining the ability to correct both the deficient ion transport and the deregulated inflammatory responses.
Likewise, releasate from washed platelets, even from plasma Factor XI-deficient donors, was able to correct the clotting defects observed in Factor XI-deficient plasma in vitro [35].
This demonstrates the ability of human VLCAD to correct the biochemical phenotype of VLCAD-deficient mice.
Treatment options to prevent or correct the anterior superior instability must substitute for the deficient rotator cuff.
Exogenous IL-2 or culture with wild-type T cells could correct the defective expansion of the PKCθ-deficient T cells, which is similar to the observations with the tolerant T cells analysed in this study.
81 A similar transplantation experiment with CGI-58-deficient mice failed to correct the skin phenotype arguing for a skin autonomous pathology.
Heterozygous deficiency of Kif3a in Pkd1 deficient mice corrects the effects of Pkd1 deficiency to lower bone mass (Fig. 2A and 2B) and mineral apposition rate (MAR) (Fig. 2C).
Leptin treatment corrects the hypogonadism of leptin-deficient ob/ob mice [ 30, 31] and starved normal mice [ 32], accelerates the onset of puberty in rodents and increasing leptin levels may signal the onset of puberty in boys and girls [ 33, 34].
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CEO of Professional Science Editing for Scientists @ prosciediting.com